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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/PFM 01/6222/50/50 mg

Tocris/PFM 01/6222/50/50 mg

价格
￥6300.00
货号：6222/50
浏览量：127
品牌：Tocris
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商品描述
Description: MRE11 endonuclease inhibitor
Chemical Name: (5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone
Purity: ≥98% (HPLC)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

MRE11 endonuclease inhibitor. Prevents double-stranded break (DSB) resection. Enhances non-homologous end-joining (NHEJ) and reduces homologous recombination.

Technical Data

M. Wt 293.4
Formula C14H15NO2S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1558598-41-6
PubChem ID 2145809
InChI Key GPURHDUTZUYAFI-GHXNOFRVSA-N
Smiles CC(CN1C(S/C(C1=O)=CC2=CC=C(C=C2)O)=S)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.34 100
ethanol 29.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 293.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.41 mL 17.04 mL 34.08 mL
5 mM 0.68 mL 3.41 mL 6.82 mL
10 mM 0.34 mL 1.7 mL 3.41 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

Product Datasheets

Certificate of Analysis / Product Datasheet
Safety Datasheet

References

References are publications that support the products' biological activity.

Shibata et al (2014) DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol.Cell 53 7 PMID: 24316220

Keywords: PFM 01, supplier, PFM01, MRE11, meiotic, recombination, 11, homolog, A, endonuclease, inhibitors, inhibits, non-homologous, end-joining, NHEJ, recombination, HR, DNA,, RNA, and, Protein, Synthesis, DNA,, RNA, and, Protein, Synthesis, Tocris Bioscience

我们的目的是通过提供全球范围内性能最高，最具创新性的研究试剂，使新的生命科学发现成为可能。 我们所做的 Tocris Bioscience是高性能生命科学试剂，肽和抗体的领先供应商，其客户几乎遍布全球所有主要的制药公司，大学和研究机构。该公司致力于通过提供最具创新性的高纯度产品来推动生命科学研究。我们的1,800多种试剂目录代表着独特的，新颖的，专有的和许可的研究工具，并且每年发送给全球50,000多名科学家。Tocris产品供科学家在癌症，心血管疾病，疼痛和感染等领域进行非临床研究时使用。