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Biological Activity
Active enantiomer of AMPA (EC50 = 3.5 μM). Also available as part of the AMPA Receptor Tocriset™ (Cat. No. 1822). NPEC-caged-(S)-AMPA (Cat. No. 3840), inactive enantiomer (R)-AMPA (Cat. No. 0253) and racemate (RS)-AMPA (Cat. No. 0169) are also available.
Technical Data
| M. Wt | 186.17 |
| Formula | C7H10N2O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 83643-88-3 |
| PubChem ID | 158397 |
| InChI Key | UUDAMDVQRQNNHZ-YFKPBYRVSA-N |
| Smiles | [H][C@@](N)(C(O)=O)CC1=C(C)ON=C1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 18.62 | 100 | |
| water | 18.62 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 186.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.37 mL | 26.86 mL | 53.71 mL |
| 5 mM | 1.07 mL | 5.37 mL | 10.74 mL |
| 10 mM | 0.54 mL | 2.69 mL | 5.37 mL |
| 50 mM | 0.11 mL | 0.54 mL | 1.07 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Falch et al (1998) Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships. J.Med.Chem. 41 2513 PMID: 9651156
Hansen et al (1983) Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid. J.Med.Chem. 26 901 PMID: 6133955
Lauridsen et al (1985) Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors. J.Med.Chem. 28 668 PMID: 2859375
Keywords: (S)-AMPA, supplier, Selective, AMPA, agonists, Glutamate, Receptors, iGluR, Ionotropic, AMPA, Receptors, AMPA, Receptors, Tocris Bioscience
