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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/Lonafarnib/6265/10/10 mg

Tocris/Lonafarnib/6265/10/10 mg

价格
￥2500.00
货号：6265
浏览量：127
品牌：Tocris
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商品描述
Description:Potentfarnesyltransferaseinhibitor
ChemicalName:4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentfarnesyltransferaseinhibitor(IC50=1.9nM).InhibitsfarnesylationofRAS.AlsoinhibitsPgptransport(IC50<3=""μm)=""and=""increases=""potency=""and=""anticancer=""activity=""when=""used=""in=""conjunction=""with=""cytotoxic=""pgp=""substrates.=""inhibits=""neovascularization=""by=""affecting=""cell=""motility.=""orally="">

TechnicalData

M.Wt638.82
FormulaC27H31Br2ClN4O2
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber193275-84-2
PubChemID148195
InChIKeyDHMTURDWPRKSOA-RUZDIDTESA-N
SmilesNC(N1CCC(CC1)CC(N2CCC([C@H]3C4=NC=C(C=C4CCC5=CC(Cl)=CC(Br)=C35)Br)CC2)=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO6.3910mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight638.82.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.57mL7.83mL15.65mL
5mM0.31mL1.57mL3.13mL
10mM0.16mL0.78mL1.57mL
50mM0.03mL0.16mL0.31mL