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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/PF 04620110/5863/5/5 mg

Tocris/PF 04620110/5863/5/5 mg

价格
￥1700.00
货号：5863
浏览量：127
品牌：Tocris
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商品描述
Description:PotentandselectiveDGAT-1inhibitor;orallybioavailable
ChemicalName:trans-4-[4-(4-Amino-7,8-dihydro-5-oxopyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]cyclohexaneaceticacid
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveDGAT-1inhibitor(IC50=19nM).Exhibits>1000-foldselectivityforDGAT-1overDGAT-2,andnosignificantactivityagainstarangeofotherenzymes,ionchannelsandreceptors.Reducesplasmatriglyceridelevelsinaratlipidchallengemodel.Orallybioavailable.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

TechnicalData

M.Wt396.44
FormulaC21H24N4O4
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber1109276-89-2
PubChemID46926360
InChIKeyGEVVQZHMFVFGLN-UHFFFAOYSA-N
SmilesO=C1N(C2=CC=C([C@@H]3CC[C@@H](CC(O)=O)CC3)C=C2)CCOC4=NC=NC(N)=C41

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO7.9320

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight396.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.52mL12.61mL25.22mL
5mM0.5mL2.52mL5.04mL
10mM0.25mL1.26mL2.52mL
50mM0.05mL0.25mL0.5mL