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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/氯氮平N-氧化物/4936/50/50 mg

Tocris/氯氮平N-氧化物/4936/50/50 mg

价格
￥11580.00
货号：4936/50
浏览量：127
品牌：Tocris
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商品描述
Description:ActivatorofmuscarinicDREADDs
ChemicalName:8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Metaboliteofclozapine(Cat.No.0444).Activateshumanmuscarinicdesignerreceptors(DREADDs)invitro.SilenceshippocampalneuronsexpressinghM4DREADDsinvitro.ActivatesGs-linkedDREADDS-AgRPinmiceviaintracerebroventricular(i.c.v)injection.ShowntobeaP-glycoprotein(P-gp)effluxpumpsubstrate.Watersolublesalt(Cat.No.6329)alsoavailable.OtherpotentandselectivehM3DqDREADDagoNISTsavailable:DREADDagonist21(Cat.No.5548)andPerlapine(Cat.No.5549)

TechnicalData

M.Wt342.82
FormulaC18H19ClN4O
StorageStoreatRT
Purity≥99%(HPLC)
CASNumber34233-69-7
PubChemID2819
InChIKeyWYRDWWAASBTJLM-UHFFFAOYSA-N
SmilesClC(C=C3)=CC1=C3NC(C=CC=C2)=C2C(N4CC[N+](C)([O-])CC4)=N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO6.8620
ethanol3.4310mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight342.82.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.92mL14.58mL29.17mL
5mM0.58mL2.92mL5.83mL
10mM0.29mL1.46mL2.92mL
50mM0.06mL0.29mL0.58mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet