DescriptionSequence(One-Letter Code)

Product Name	LSKL, Inhibitor of Thrombospondin (TSP - 1)LSKL - NH2
Size	1 mg
Catalog #	AS-60877
US$	$68
Purity	% Peak Area By HPLC ≥ 95%
This peptide, derived from the latency-associated peptide, inhibits thrombospondin (TSP-1) activation of TGF-ß; thus preventing the progression of hepatic damage and fibrosis.
Detailed Information	Datasheet Material Safety Data Sheets (MSDS)
Storage	-20°C
References	Ref: Ribeiro, SM. et al. J. Biol. Chem. 274, 13586 (1999); Kondou, H. et al. J. Hepatol. 39, 742 ( 2003).
Molecular Weight	458.6
LSKL-NH2
Sequence(Three-Letter Code)	H - Leu - Ser - Lys - Leu - NH2
Product Citations	Pallero, M.A. et al. (2010). Stainless steel ions stimulate increased thrombospondin-1-dependent TGF-Beta activation by vascular smooth muscle cells: implications for in-stent restenosis Vasc Res47 doi: 10.1159/000265565. Wang, S. et al. (2010). Glucose downregulation of PKG-I protein mediates increased thrombospondin1-dependent TGF-β activity in vascular smooth muscle cells. Am J Physiol Cell Physiol doi:10.1152/ajpcell.00330.2009.Xie, X. et al. (2010). LSKL, a peptide antagonist of thrombospondin-1, attenuates renal interstitial fibrosis in rats with unilateral ureteral obstruction. Archives Pharmac Res33 doi: 10.1007/s12272-010-0213-6. Belmadani, S. et al. (2007). A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II. Am J Patholdoi:10.2353/ajpath.2007.070056.Zhou, Y. et al. (2004). Thy-1 Expression Regulates the Ability of Rat Lung Fibroblasts to Activate Transforming Growth Factor-β in Response to Fibrogenic Stimuli Am J Pathol165

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