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蚂蚁淘在线 / 品牌中心 / Xcess / Xcessbio/PR-619, Deubiquitinylating Enzyme (DUB) Inhibitor -Xcessbio Biosciences Inc/2 mg solid/M60199-2s

Xcessbio/PR-619, Deubiquitinylating Enzyme (DUB) Inhibitor -Xcessbio Biosciences Inc/2 mg solid/M60199-2s

价格
￥1180.00
货号：M60199-2s
浏览量：127
品牌：Xcess
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Product Information
Molecular Weight:223.28
Formula:C7H5N5S2
Purity:≥98%
CAS#:2645-32-1
Solubility:DMSO up to 100 mM
Chemical Name:3,5-dithiocyanatopyridine-2,6-diamine
Storage:Powder:4oC 1 year. DMSO:4oC3 month;-20oC 1 year.

Biological Activity:

PR-619 is a cell-permeable, non-selective, reversible broad-range inhibitor of the deubiquitinylating enzymes (DUBs) with IC50 of 1-20 μM. PR-619 is shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150 μM, 0.5 to 20 h) without direct impairment of proteasomal proteolysis. PR-619 treatment results in upregulation of both K48 - and K63-linked polyUb chains. It induces HCT116 cell death with EC50 ~6.3 μM.

How to Use:

  • In vitro:PR-619 was used at 10-50 µM final concentration in various in vitro assays.
  • In vivo: n/a

Reference:

  1. 1. Altun M, et al. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (2011) Chem Biol. 18(11):1401-12.

  • PR-619_spec.pdf
  • PR-619_MSDS.pdf

Products are for research use only. Not for human use.

Xcess生物科学公司(XcessBio)成立于2008年,由一群顶尖的科学家来自学术界和制药/生物技术产业具有较强的专业知识在药物化学、生物化学、分子和细胞生物学。