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Ananticonvulsantusedinthetreatmentofepilepsy,anorexianervosa,panicattack,anxietydisorder,posttraumaticstressdisorder,migraineandbipolardisorder.Valproateisalsoahistonedeacetylaseinhibitor(IC50=400uM)thatexhibitsanticancer,anti-inflammatoryandneuroprotectiveeffects.DisplaysanticonvulsiveactivityviaanincreaseinGABAlevelsanddecreasesAbetaproductioninanimalmodelsofAlzheimer’sdisease.AlsoattenuatesNMDA-mediatedexcitation,blocksvoltage-gatedNa+channelsandmodulatesfiringofneurons.Enablesinduction ofpluripotentstemcellsfromsomaticcellsbyOct4andSox2.Valproicacidalsoinhibitsglycogensynthasekinase3(GSK3)anddepletescellularinositol-1,4,5-trisphosphate(1,4,5-IP3).ValproicacidshowspromiseincombinationtherapyforcancerandintreatingAlzheimer’sdisease.InhibitsClassIHDACswithanIC50valueof~2mM.
