Specifications

Background

Semisynthetic alkaloidal anticancer agent. Induces cell cycle arrest at G2/M phase by inhibiting mitotic spindle formation1. Inhibits normal microtubule assembly and induces aberrant tubulin polymerization1. Induces apoptosis in a variety of cell lines2. Inhibits autophagosome maturation3. Inhibits palmitoylation of tubulin4. Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.

Product Information

Purity:                                       98% by TLCMW:                                           909.1Formula:                                   C46H58N4O9. H2SO4CAS No.                                     143-67-9Physical State:                          Lyophilized white crystalline powderAmount:                                   5mg, 25mgSolubility:                                 25 mg/mL in DMSO; 50 mg/mL in waterStorage:                                    Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 1 month.

References

1. E Hamel Med. Res. Rev. 1996 16:2072. K Tsukidate et al. Am. J. Pathol. 1993 143:9183. CP Satori et al. Anal. Chem. 2013 85:113914. JM Caron and M Herwood Chemotherapy 2007 53:51

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