- Peptide Substrates
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- E3
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Overview:
NPR1ornatriureticpeptidereceptor1isamembrane-boundguanylatecyclasethatservesasthereceptorforbothatrialandbrainnatriureticpeptides(1).NPR1expressioninfluencesbloodpressuresofmiceinadose-dependentmanner.ANPandNPR1bindinginducesanincreaseinintracellularcGMPwhichinitiatesnatriuresis,diuresis,andvasodilation,allofwhichcontributetoloweringbloodpressure.LowNpr1expressionleadstoasalt-sensitiveincreaseinBP,whereashighNpr1expressionlowersBPandprotectsagainsthighdietarysalt(2).
GeneAliases:
ANPa,GUC2A,GUCY2A
GenbankNumber:
BC063304
References:
1.Garbers,D.L.et.al:Guanylylcyclasereceptors.J.Biol.Chem.269:30741-30744,1994.2.Oliver,P.M.et.al:Natriureticpeptidereceptor1expressioninfluencesbloodpressuresofmiceinadose-dependentmanner.Proc.Nat.Acad.Sci.95:2547-2551,1998.
