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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/PF 429242/3354/10/10 mg

Tocris/PF 429242/3354/10/10 mg

价格
￥4500.00
货号：3354/10
浏览量：127
品牌：Tocris
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商品描述
Description:CompetitiveinhibitorofSREBPsite1protease
ChemicalName:4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

ReversIBLe,competitiveinhibitorofsterolregulatoryelement-bindingprotein(SREBP)site1protease(IC50=0.175μM).Selectiveforsite1proteaseagainstapanelofserineproteases.InhibitsrateofcholesterolsynthesisinCHOcells(IC50=0.53μM).Alsodisplaysantiviralactivity.Cellpermeable.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

CompoundLibraries

PF429242isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt482.49
FormulaC25H35N3O2.2HCl
StorageDesiccateatRT
Purity≥97%(HPLC)
CASNumber947303-87-9
PubChemID90488837
InChIKeyGSUZWFZKTIOWTI-MQWQBNKOSA-N
SmilesO=C(C2=CC=C(CN(CC)CC)C=C2)N(CCC3=CC=CC=C3OC)[C@@H]1CCNC1.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO24.1250
ethanol48.25100
water24.1250

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight482.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.07mL10.36mL20.73mL
5mM0.41mL2.07mL4.15mL
10mM0.21mL1.04mL2.07mL
50mM0.04mL0.21mL0.41mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet